Pathophysiology: The Biologic Basis for Disease in Adults and Children

Key differences between 7th and 6th editions

• Period between current and previous publications: 4 years (2013 vs 2009).
• McCance's Pathophysiology text was originally published in 1990.
• Chapter 1 presents updated material on cellular organelles, the plasma membrane, cell signaling, and communication.
• Chapter 2 presents updated material on agents of cell injury, oxidative stress, apoptosis, and aging.
• New Chapter 6 "Epigenetics and Disease", covering:
• Epigenetics and Development
• Genomic Imprinting
• Future Directions Unit III Mechanisms of Self-Defense
• Chapters 7 and 8 provide fresh material on normal innate and adaptive immunity.
• Chapter 9 presents updated material on alterations of immunity and inflammation.
• Chapter 10 provides material on emerging infections.
• Chapter 11 has been reorganized and updated. New topic "Neuroendocrine Regulation".
• Chapter 16 presents new topic "Rapid Eye Movement Sleep", updated content on chronic pain syndromes and classification of sleep disorders.
• Chapter 17 presents updated material on alterations in consciousness, memory, delirium syndromes, and dementia. New information about Parkinson disease and amyotrophic lateral sclerosis.
• Chapter 20 presents new topic "Epilepsy".
• Chapter 22 on alterations of hormonal regulation has been extensively updated.
• Former Sixth edition's chapter "Alterations of the Reproductive Systems" now is presented in two separate chapters 24 "Alterations of the Female Reproductive System" and 25 "Alterations of the Male Reproductive System".
• Chapter 29 provides updated material on alterations of leukocyte, lymphoid, and hemostatic function.
• Chapter 31 has been extensively rewritten.
• Chapter 32 presents considerably updated material on atherosclerosis, endothelial injury and dysfunction, coronary artery disease, myocardial infarction, and heart failure.
• Chapter 35 has new content on Viral Pneumonia.
• Chapter 36 has been significantly updatedand and presents separate sub-sections on many pulmonary disorders, including Upper Airway Obstruction, Respiratory Distress Syndrome of the Newborn, Bronchopulmonary, Dysplasia Respiratory Tract Infections, Aspiration Pneumonitis, Bronchiolitis Obliterans, Asthma, Acute Lung Injury, and Cystic Fibrosis.
• Chapter 39 provides new material on urinary tract infection, glomerulonephritis, and renal failure in children.
• Chapter 42 provides new material on gluten-sensitive enteropathy, necrotizing enterocolitis, bowel obstruction, infections of the intestine,and liver disease in children.
• Chapters 48 and 49 on shock, multiple organ dysfunction syndrome, and burns have been significantly updated and reorganized.