Genetics: From Genes to Genomes

Key differences between 6th and 5th editions

• Period between previous and current publications: 3 years (2017 vs 2014).
• Hartwell's Genetics text was originally published in 1999.
• The content in the 6e textbook has been greatly updated and modernized, includes many new Fast Forward boxes, examples, and end-of-chapter problems.
• Former Chapter 9 was split into two separate chapters 9 and 10
• Chapter 4: New Fast Forward box - scientists of Johns Hopkins University School of Medicine have generated transgenic mice in which X chromosome inactivation can be visualized in individual cells.
• Chapter 6: New section about conservative site-specific recombination process.
• Chapter 7: New section of mechanisms of DNA damage response and repair.
• Chapter 9: Better explanation of whole-genome shotgun sequencing technology.
• Chapter 10:
• New illustration of consensus amino acid sequences in proteins.
• New information about the process of de novo gene birth.
• Chapter12: New material on design and synthesis of yeast chromosomes.
• Chapter 15: New Fast Forward box on concept of a Mitochondrial Eve, the maternal ancestor of all living humans.
• Chapter 17:
• New Tools of Genetics box on Gal4/upstream activating sequence (UAS) binary gene expression system, a powerful functional tool for manipulating gene expression.
• New material about Trans-acting proteins regulating translation.
• Chapter 18:
• New material on CRISPR-Cas9 technology that enables targeted genome editing.
• New Tools of Genetics box How bacteria protects themselves from viruses that revealed the structural basis by which bacteria 'steal' foreign DNA for use in their own immunological system.
• New Tools of Genetics box features research that revealed how bacteria protects themselves from viruses and explains mechanism how bacteria 'steal' foreign DNA for use in their own immunological system.
• New Genetics and Society box about issues of changing the human germ line.
• Chapter 22: New explanation of how to use Chi-Square test of independence (Pearson Chi-square test) for genome-wide association studies.