Lehninger Principles of Biochemistry

Key differences between 7th and 6th editions

• Time lapse between current and previous publications: 4 years (2012 vs 2008).
• The First Ed. of Principles of Biochemistry appeared in 1970 and was written by Albert Lehninger.
• The Seventh Ed. offers new biochemical simulations, case studies, and interactive metabolic map.
• New and additional material in the Seventh Edition:
• Chapter 1: Artificial cells and human disease genomics
• Chapter 4: Intrinsically disordered protein (IDP)
• Chapter 6: Presteady state kinetics of enzymatic reactions
• Chapter 8:
• Single-molecule real-time (SMRT) sequencing method
• Ion Torrent sequencing technology
• Chapter 9:
• DNA annotation
• CRISPR-Cas9, a genome editing technique
• Chapter 10:
• LIPID MAPS structure database
• Guillain Barre syndrome and anti-ganglioside antibodies
• Golden Rice and vitamin A deficiency
• Chapter 11:
• Amphitropic proteins regulation by reversible membrane interactions
• Cystic fibrosis (a genetic disorder that affects the lungs) and its treatment
• Gliflozin drugs (SGLT2 inhibitors) in the treatment of type 2 diabetes
• Chapter 12: Role of Intrinsically disordered proteins in cellular signaling
• Chapter 13: Importance of nicotinamide adenine dinucleotide + hydrogen (NADH)
• Chapter 17: Screening newborns for acylcarnitine as a marker for metabolic disorders.
• Chapter 18: Methylglyoxal induced type-2 diabetes
• Chapter 19:
• Cryo-electron microscopy
• Three-parent babies - the science of mitochondrial replacement therapy
• New Chapter 20: covers photosynthesis and carbohydrate biosynthesis in plants and bacteria
• Chapter 21: Specialized pro-resolving lipid mediators (SPMs), molecules formed in cells by the metabolism of essential fatty acids spectrum
• Chapter 23:
• Role of incretin in blood glucose regulation; exercise-induced hormone irisin
• Disruption of normal endocrine function by environmental xenobiotics
• Thermogenesis in brown and beige adipose tissues
• Chapter 24: Chromosome territories
• Chapter 26:
• Spliceosome, a dynamic complex molecular machine
• Machanism of cap snatching
• Chapter 28: RNA recognition motif (RRM), an abundant protein domain in eukaryotes