Molecular Cell Biology (Lodish)

Key differences between 8th and 7th editions

• Time lapse between current and previous publications: 4 years (2016 vs 2012).
• This textbook was first published in 1999.
• The 8th Edition is available in lower cost Loose Leaf print format.
• New co-author, Kelsey Martin, a Professor of Biological Chemistry and Psychiatry at the University of California, Los Angeles.
• List of new discoveries and research in the Eighth Ed:
• Chapter 1: New model organisms for research, including Chlamydomonas reinhardtii, Plasmodium falciparum.
• Chapter 3:
• Intrinsically disordered proteins.
• The amyloid state and unfolded proteins related to disease.
• Hydrogen/deuterium exchange mass spectrometry tool for analysis of protein structure.
• Phosphoproteomics.
• Chapter 4:
• Two-photon excitation microscopy, a fluorescence imaging technique.
• Light sheet microscopy (single plane illumination microscopy).
• Three-dimensional cell culture matrices.
• Chapter 6: CRISPR/Cas9 system and targeted genome editing.
• Chapter 8: Topological domains in chromosome territories within the nucleus.
• Chapter 9:
• Whole-genome mapping of DNase I-hypersensitive sites explains cell developmental history.
• Role of Long Non-coding RNAs in X-chromosome inactivation.
• Chapter 11: Human GLUT1 molecular model.
• Chapter 15: G protein coupled receptors (GPCRs) as important targets in modern pharmacology.
• Chapter 16:The role of adipose tissue in inflammation.
• Chapter 17:Troponins as unique indicators of heart muscle damage.
• Chapter 19:
• Hippo signaling pathway.
• Association between nondisjunction and maternal age.
• Chapter 20:
• Mechanotransduction, the physiologic process of conversion of mechanical signals into biochemical responses.
• Tunneling nanotubes as an emerging intercellular communication route.
• Chapter 21: Pluripotent stem cells.
• Chapter 22:
• Optogenetic techniques for analyzing the neural circuits of behavior.
• Synaptic plasticity and mechanism of learning and memory at the neuronal level.
• Chapter 23:
• The nucleic acid-sensing inflammasomes.
• T cell lineage commitment.